Phenotypic and genomic evolution along the line of decent in the case-study population through the origin of the EQU function at step 111

The entire line of decent is available at lenski.mmg.msu.edu/papers/nature2003/ along with functional-genomic arrays for all 345 genotypes in the line of descent.

Legend: PD = phylogenetic depth. Born = update when genotype first appeared. Function 0 and 1 senoter intability or ability, respectively, to perform nine logic functions: NOT, NAND, AND, OR_N, OR, AND_N, NOR, XOR, and EQU. Fit = fitness relative to immediate parent caclulated as product of replication efficiency and computational merit gains are shown in green, losses in red. Mutations are highlighted by color: point mutations are printed in red, insertions in green; deletions are marked by blue underscores.

PD Born Functions Repl. Fit. Genome Sequence
0 0 0 0 0 0 0 0 0 0 0 0 0 rucavccccccccccccccccccccccccccccccccccccutycasvab
1 32 0 0 0 0 0 0 0 0 0 1 1 rucavccccccccccccccccccccccccccccchccccccutycasvab
2 93 0 0 0 0 0 0 0 0 0 1.00532 1.00532 rucavcccccccccccccccccccccccccpcccchccccccutycasvab
3 143 0 0 0 0 0 0 0 0 0 1.3617 1.3617 rucavcccccccccccccccccccccccccp_ccchccccccutycastvab
4 225 0 0 0 0 0 0 0 0 0 1.00714 1.00714 rucavcccccccccccccccccccccccccpcnchccccccutycastvab
5 284 0 0 0 0 0 0 0 0 0 1.01449 1.01449 rucavcczccccccccccccccccccccccpcnchccccqcutycastvab
6 352 0 0 0 0 0 0 0 0 0 1 1 rucavcczccccccccccccccccccccccqcnchccccqcutycastvab
7 361 0 0 0 0 0 0 0 0 0 1 1 rucavcozccccccccccccccccccccccqcnchccccqcutycastvab
8 379 0 0 0 0 0 0 0 0 0 1.0073 1.0073 rucavcozcccccccccccccccccccxccqcnchccccqcutycastvab
9 411 0 0 0 0 0 0 0 0 0 1 1 rucavcozcccccccccccccccccacxccqcnchccccqcutycastvab
10 567 0 0 0 0 0 0 0 0 0 1 1 rucavcozcccccccccccccccccacxecqcnchccccqcutycastvab
11 734 0 0 0 0 0 0 0 0 0 1 1 rucavcozcccccccccccccccccamxecqcnchccccqcutycastvab
12 775 0 0 0 0 0 0 0 0 0 1 1 rucavcozcccscccccccccccccamxecqcnchccccqcutycastvab
13 793 0 0 0 0 0 0 0 0 0 0.986366 0.986366 rucavcozcccscicccccccccccamxecqcnchccccqcutycastvab
14 835 0 0 0 0 0 0 0 0 0 1 1 rucavcozcccscicccccccccccamxelqcnchccccqcutycastvab
15 949 0 0 0 0 0 0 0 0 0 1 1 rucavcozjccscicccccccccccamxelqcnchccccqcutycastvab
16 963 0 0 0 0 0 0 0 0 0 0.992701 0.992701 rucavcozjccscicccccccccccamxelqcnqhccccqcutycastvab
17 1118 0 1 0 0 0 0 0 0 0 1.00735 2.01471 rucavcozjccscicccccccccccamxelqcnqhccpcqcutycastvab
18 1194 0 1 0 0 0 0 0 0 0 1.01382 1.01382 rucavcotzjccscicccccccccccamxelqcnqhccpcqcutycastvab
19 1250 0 1 0 0 0 0 0 0 0 1.01344 1.01344 rucavcotzjciscicccccccccccamxelqcnqhccpcqcutycastvab
20 1252 0 0 0 1 0 0 0 0 0 1.0073 2.0146 rucavcotzjciscicccccccccccamxelqcnqhpcpcqcutycastvab
21 1263 0 0 0 1 0 0 0 0 0 1.00152 1.00152 rucavcotzjciscicccnccccckcamqelqcnqhpcpcqcutycastvab
22 1289 0 1 0 1 0 0 0 0 0 1 2 rucavcotzjciscicccnccccckcamqelqcpqhpcpcqcutycastvab
23 1325 0 1 0 1 0 0 0 0 0 1 1 rucavcotzjcisciccdnccccckcamqelqcpqhpcpcqcutycastvab
24 1433 0 1 0 1 0 0 0 0 0 0.994003 0.994003 rucavcotzjcisciccdnceccckcamqelqcpqhpcpcqcutycastvab
25 1439 0 1 0 1 0 0 0 0 0 1.15221 1.15221 rucavcotzjcisciccdnceccckcamqelqcpqhpcpcqcutycasttvab
26 1455 0 1 0 1 0 0 0 0 0 0.991525 0.991525 rucavcotzjcisciccdnceccckramqelqcpqhpcpcqcutycasttvab
27 1645 0 1 0 1 0 0 0 0 0 1.01225 1.01225 rucavcotzjaisciccdnceccckramqelqcpqhpcpcqcutycasttvab
28 1910 0 1 0 1 0 0 0 0 0 1 1 rucavcotzjaisciccdncecccyramqelqcpqhpcpcqcutycasttvab
29 1947 0 1 0 1 0 0 0 0 0 0.979592 0.979592 rucavcotzsaisciccdncecccyramqelqcpqhpcpcqcutycasttvab
30 2286 0 1 0 1 0 0 0 0 0 1.01233 1.01233 rucavcotzsaisciccdnceiccyramqelqcpqhpcpcqcutycasttvab
31 2479 0 1 0 1 0 0 0 0 0 1 1 rucavcotzsajsciccdnceiccyramqelqcpqhpcpcqcutycasttvab
32 2669 0 1 0 1 0 0 0 0 0 1 1 rucavcotdsajsciccdnceiccyramqelqcpqhpcpcqcutycasttvab
33 2711 0 1 0 1 0 0 0 0 0 1.0084 1.0084 rucavcotdqajsciccdnceiccyramqelqcpqhpcpcqcutycasttvab
34 2786 1 1 0 1 0 0 0 0 0 1 2 rucavcotdqajsciccdncoiccyramqelqcpqhpcpcqcutycasttvab
35 2828 1 1 0 1 0 0 0 0 0 1 1 rucavcotdqaqsciccdncoiccyramqelqcpqhpcpcqcutycasttvab
36 2830 1 1 0 1 0 0 0 0 0 0.991667 0.991667 rucavcotdqaqsciccdncosccyramqelqcpqhpcpcqcutycasttvab
37 2987 1 1 0 1 0 0 0 0 0 1 1 rucavcotdqaqsciccdncosccyramqetqcpqhpcpcqcutycasttvab
38 3420 1 1 0 1 0 0 0 0 0 1.03221 1.03221 rucavcotdqaqsqciccdncosccyramqetqcpqhpcpcqcutycasttvab
39 3551 1 1 0 1 0 0 0 0 0 1 1 rucavcitdqaqsqciccdncosccyramqetqcpqhpcpcqcutycasttvab
40 3808 0 1 1 1 0 0 0 0 0 1 2 rucavcitdqaqsqcpccdncosccyramqetqcpqhpcpcqcutycasttvab
41 3914 0 1 1 1 0 0 0 0 0 1.00833 1.00833 rucavcitdqaqsqcpccdncosccypamqetqcpqhpcpcqcutycasttvab
42 3939 0 1 1 1 0 1 0 0 0 1 8 rucavcitdqaqsqcpcldncosccypamqetqcpqhpcpcqcutycasttvab
43 4190 0 1 1 1 0 1 0 0 0 1 1 rucavcotdqaqsqcpcldncosccypamqetqcpqhpcpcqcutycasttvab
44 4646 0 1 1 1 0 1 0 0 0 1.08277 1.08277 rucavcotdqaqsqcpcldncosccypamqetqcpqhpcpcqcutycastttvab
45 5292 0 1 1 1 0 1 0 0 0 1 1 rucavcotdqaqsqcpcldncosccypamqrtqcpqhpcpcqcutycastttvab
46 5302 0 1 1 1 0 1 0 0 0 1 1 rucavcotdqaqsqcpcldncosccdpamqrtqcpqhpcpcqcutycastttvab
47 5323 0 1 1 1 0 1 0 0 0 0.991228 0.991228 ruzavcotdqaqsqcpcldncosccdpamqrtqcpqhpcpcqcutycastttvab
48 5337 0 1 1 1 0 1 0 0 0 0.991304 0.991304 ruzavcotdqaqsqcpcldncosccdpamqrtqcpqhpgpcqcutycastttvab
49 5481 0 1 1 1 0 1 0 0 0 1.01923 1.01923 ruzavcotcqaqsqcpcldncosccdpamqrtqcpqhpgpcqcutycastttvab
50 6067 0 1 1 1 0 1 0 0 0 1 1 ruzavcotiqaqsqcpcldncosccdpamqrtqcpqhpgpcqcutycastttvab
51 6200 0 1 1 1 0 1 0 0 0 1 1 ruzavcotizaqsqcpcldncosccdpamqrtqcpqhpgpcqcutycastttvab
52 6520 0 1 1 1 0 1 0 0 0 1.00877 1.00877 ruzavcotizaqsqcpcldncosccdpamqbtqcpqhpgpcqcutycastttvab
53 6765 0 1 1 1 0 1 0 0 0 1 1 rjzavcotizaqsqcpcldncosccdpamqbtqcpqhpgpcqcutycastttvab
54 7117 0 1 1 1 0 1 0 0 0 1.01001 1.01001 rjzavcottizaqsqcpcldncosccdpamqbtqcpqhpgpcqcutycastttvab
55 7478 0 1 1 1 0 1 0 0 0 1 1 rmzavcottizaqsqcpcldncosccdpamqbtqcpqhpgpcqcutycastttvab
56 7565 0 1 0 1 0 1 1 0 0 1 4 rmzavcottizaqpqcpcldncosccdpamqbtqcpqhpgpcqcutycastttvab
57 7977 0 1 0 1 0 1 1 0 0 1.00877 1.00877 rmzavcottizaqpqcpcldncoszcdpamqbtqcpqhpgpcqcutycastttvab
58 8443 0 1 0 1 0 1 1 0 0 0.991304 0.991304 rmzavcottizaqpqcpcldncoszcdpamqgtqcpqhpgpcqcutycastttvab
59 8742 0 1 0 1 0 1 1 0 0 0.991379 0.991379 rmzavcottizpqpqcpcldncoszcdpamqgtqcpqhpgpcqcutycastttvab
60 8777 0 1 0 1 0 1 1 0 0 1 1 rmzavcothtizpqpqcpcldncoszcdpamqgtqcpq_pgpcqcutycastttvab
61 9399 1 1 0 1 0 1 1 0 0 0.991453 1.98291 rmzavcothoiqpqpqcpcldncosztdpamqgtqcpqpgpcqcutycastttvab
62 9428 1 1 0 1 0 1 1 0 0 1 1 rmzavcothhiqpqpqcpcldncosztdpamqgtqcpqpgpcqcutycastttvab
63 9582 1 1 0 1 0 1 1 0 0 0.316933 0.316933 rmzavcothhiqpqpqcpcldncosztdpamqgtqcpqpsgpcqcutycastttvab
64 9590 1 1 0 1 0 1 1 0 0 3.18644 3.18644 rmzavcothhiqpqpqcpcltncosztdpamqgtqcpqpsgpcqcutycastttvab
65 9823 1 1 0 1 0 1 1 0 0 1 1 rmzavcotehiqpqpqcpcltncosztdpamqgtqcpqpdgpcqcutycastttvab
66 9993 1 1 0 1 0 1 1 0 0 1 1 rmzavcotehiqpqpqcpcltncorztdpamqgtqcpqpdgpcqcutycastttvab
67 11029 1 1 0 1 0 1 1 0 0 1.00963 1.00963 rmzavcotehiqpqpqcpctltncorztdpamqgtqcpqpdgpcqcutycastttvab
68 11584 1 1 0 1 0 1 1 0 0 1.00937 1.00937 rmzavcotehiqptqpqcpctltncorztdpamqgtqcpqpdgpcqcutycastttvab
69 12028 1 1 0 1 0 1 1 0 0 1.0084 1.0084 rmzavcotebiqptqpqcpctltncorztdpamqgtqcpqpdgpcqcutycastttvab
70 12671 1 1 0 1 0 1 1 0 0 1.00847 1.00847 rmzavcytebiqptqpqcpctltncorztdpamqbtqcpqpdgpcqcutycastttvab
71 12853 1 1 0 1 0 1 1 0 0 1 1 rmzavcytebiqptqpqcpctltncorctdpamqbtqcpqpdgpcqcutycastttvab
72 12947 1 1 0 1 0 1 1 0 0 0.991597 0.991597 rmzavcytebiqptqpqcpctltncorctdpamqztqcpqpdgpcqcutycastttvab
73 13119 1 1 0 1 0 1 1 0 0 1 1 rmzavcytnbiqptqpqcpctltncorctdpamqztqcpqpdgpcqcutycastttvab
74 13537 1 1 0 1 0 1 1 0 0 1 1 rmzavcztnbiqptqpqcpctltncorctdpamqztqcpqpdgpcqcutycastttvab
75 13557 1 1 0 1 0 1 1 0 0 1 1 rmzavcztnbiqptqpqcpctltncorctdpamqstqcpqpdgpcqcutycastttvab
76 13869 1 1 0 1 0 1 1 0 0 1 1 rmzavcztnbiqptqpqcpctltncorctdpamqdtqcpqpdgpcqcutycastttvab
77 13952 1 1 0 1 0 1 1 0 0 1.00847 1.00847 rmzavcztnbiqptqpqcpctltncorctdpamqdtqcpqpdbpcqcutycastttvab
78 14478 1 1 0 1 0 1 1 0 0 1 1 rmzavcztnbiqptqpqcpctltncorctdpamqdtqcpqpcbpcqcutycastttvab
79 15603 1 1 0 1 0 1 1 0 0 1 1 rmzavcztwbiqptqpqcpctltncorctdpamqdtqcpqpcbpcqcutycastttvab
80 15769 1 1 0 1 0 1 1 0 0 1.00855 1.00855 rmzavcztwbiqptqpqcpctltncogctdpamqdtqcpqpcbpcqcutycastttvab
81 15936 1 1 0 1 0 1 1 0 0 1 1 rmzavcztwbiqptqpqcpctltncogctbpamqdtqcpqpcbpcqcutycastttvab
82 16039 1 1 0 1 0 1 1 0 0 1 1 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpqpcbpcqcutycastttvab
83 16090 1 1 0 1 0 1 1 0 0 1 1 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpqpibpcqcutycastttvab
84 16672 1 1 0 1 0 1 1 0 0 0.926995 0.926995 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpqpibpcqcutycas_ttvab
85 16769 1 1 0 0 1 1 1 0 0 0.992 1.984 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpqpifpcqcutycasttvab
86 16786 1 1 0 0 1 1 1 0 0 0.992063 0.992063 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpqpifpqqcutycasttvab
87 16900 1 0 0 1 1 1 1 0 0 1 2 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpepifpqqcutycasttvab
88 16979 1 0 0 1 1 1 1 0 0 1.07773 1.07773 rmzavcztwbiqptqpqcpctltncogctbnamqdtqcpepifpqqcutycastttvab
89 17008 1 0 0 1 1 1 1 0 0 1 1 rmzavcztgbiqptqpqcpctltncogctbnamqdtqcpepifpqqcutycastttvab
90 17145 1 0 0 1 1 1 1 0 0 1 1 rmzavcjtgbiqptqpqcpctltncogctbnamqdtqcpepifpqqcutycastttvab
91 17370 1 0 0 1 1 1 1 0 0 1.00906 1.00906 rmzavcjtgbiqptqpqcpctltncogctbnamqdtqcpepifpqtqcutycastttvab
92 19260 1 0 0 1 1 1 1 0 0 1.00883 1.00883 rmzavcjtgbiqptqpqcpctltncogctbnamqdtqcptepifpqtqcutycastttvab
93 19828 1 0 0 1 1 1 1 0 0 1 1 rmzavcjtgbiqptqpqcpctltncogctbnamqdtqcptipifpqtqcutycastttvab
94 20740 1 0 0 1 1 1 1 0 0 0.991243 0.991243 rmzavcjtgbiqptqpqcpctltncogctbnamqdtqcptipifpq_qcutycastttvab
95 20804 1 0 0 1 1 1 1 0 0 1 1 rmzavcjtgciqptqpqcpctltncogctbnamqdtqcptipifpqqcutycastttvab
96 21032 1 1 0 1 1 1 1 0 0 1 2 rmzavcjtdciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycastttvab
97 21509 1 1 0 1 1 1 1 0 0 1 1 rmzavcjtzciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycastttvab
98 22229 1 1 0 1 1 1 1 0 0 1 1 rmzavcatzciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycastttvab
99 22240 1 1 0 1 1 1 1 0 0 1 1 rmzavcgtzciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycastttvab
100 22404 1 1 1 1 1 1 1 0 0 0.725953 2.90381 rmzavcgtzciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycuastttvab
101 22412 1 1 1 1 1 1 1 0 0 1 1 rmzavcgtzciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycuastttva_
102 22487 1 1 1 1 1 1 1 0 0 1 1 rmzavcgtmciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycuastttva
103 22586 1 1 1 1 1 1 1 0 0 0.989118 0.989118 rmzavcg_mciqptqpqcpctltncogctbnamqdtqcptipqfpqqcutycuastttva
104 22629 1 1 1 1 1 1 1 0 0 1.04938 1.04938 rmzavcgmciqptqpqcpctletncogctbnamqdtqcptipqfpqqcutycuastttva
105 22864 1 1 1 1 1 1 1 0 0 1 1 rmzavcgmciqptqpqcpctletncogctbkamqdtqcptipqfpqqcutycuastttva
106 22886 1 1 1 1 1 1 1 0 0 0.989157 0.989157 rmzavcgmciqptqpqcpctletncogc_bkamqdtqcptipqfpqqcutycuastttva
107 23002 1 1 1 1 1 1 1 0 0 1.02179 1.02179 rmzavcgmciqqptqpqcpctletncogcbkamqdtqcptipqfpqqcutycuastttva
108 25881 1 1 1 1 1 1 1 0 0 1 1 rmzavcgmciqqptqpqcpctletncogcbqamqdtqcptipqfpqqcutycuastttva
109 26343 1 1 1 1 1 1 1 0 0 1.00617 1.00617 rmzavcgmciqqptqpqcpctletncogcbeamqdtqcptipqfpqqcutycuastttva
110 27437 1 0 1 1 1 1 1 0 0 0.987805 0.493902 rmzavcgmciqqptqpqcpctletncogcbeamqdtqcptipqfpqqxutycuastttva
111 27450 1 0 0 1 1 1 1 0 1 1 8 rmzavcgmciqqptqpqcpctletncogcbeamqdtqcptipqfpgqxutycuastttva

From the Supplementary Information for an article by Lenski, Ofria, Pennock & Adami on "The Evolutionary Origin of Complex Features" that appeared in Nature (8 May 2003), vol 423, pp 139-144.