Mutation rates

  1. Barrick, J. E., and R. E. Lenski. Genome-wide mutational diversity in an evolving population of Escherichia coli. Cold Spring Harbor Symposia on Quantitative Biology, in press. (Abstract)

  2. Barrick, J. E., D. S. Yu, S. H. Yoon, H. Jeong, T. K. Oh, D. Schneider, R. E. Lenski, and J. F. Kim. 2009. Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature 461:1243-1247. (Abstract)

  3. Lenski, R. E. 2009. Lederberg, Joshua (biographical essay). Pp. 678-680 in M. Ruse and J. Travis, eds. Evolution: The First Four Billion Years. Harvard University Press, Cambridge, Mass. (Publisher)

  4. Clune, J., D. Misevic, C. Ofria, R. E. Lenski, S. F. Elena, and R. Sanjuán. 2008. Natural selection fails to optimize mutation rates for long-term adaptation on rugged fitness landscapes. PLoS Computational Biology 4:e1000187 [8 pp]. (Article)

  5. Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proceedings of the National Academy of Sciences, USA 105:7899-7906. (Abstract) (Acrobat file)

  6. Elena, S. F., C. O. Wilke, C. Ofria, and R. E. Lenski. 2007. Effects of population size and mutation rate on the evolution of mutational robustness. Evolution 61:666-674. (Abstract)

  7. Elena, S. F., T. S. Whittam, C. L. Winkworth, M. A. Riley, and R. E. Lenski. 2005. Genomic divergence of Escherichia coli strains: evidence for horizontal transfer and variation in mutation rates. International Microbiology 8:271-278. (PDF file)

  8. Lenski, R. E., and P. Keim. 2005. Population genetics of bacteria in a forensic context. Pp. 355-369 in R. G. Breeze, B. Budowle, and S. E. Schutzer, editors. Microbial Forensics. Elsevier Academic Press, San Diego, California. (Publisher) (Acrobat file)

  9. Misevic, D., R. E. Lenski, and C. Ofria. 2004. Sexual reproduction and Muller's ratchet in digital organisms. Pp. 340-345 in J. Pollack, M. Bedau, P. Husbands, T. Ikegami, and R. A. Watson, eds. Artificial Life IX: Proceedings of the Ninth International Conference on the Simulation and Synthesis of Living Systems. MIT Press, Cambridge, Massachusetts. (Acrobat file)

  10. Lenski, R. E. 2004. The future of evolutionary biology. Ludus Vitalis (special issue honoring Ernst Mayr on his 100th birthday) 12:67-89. (Acrobat file)

  11. Lenski, R. E. 2001. Come fly, and leave the baggage behind (Perspective). Science 294:533-534. (Reprint) (Acrobat file)

  12. Wilke, C. O, J. Wang, C. Ofria, R. E. Lenski, and C. Adami. 2001. Evolution of digital organisms at high mutation rate leads to survival of the flattest. Nature 412:331-333. (Abstract) (Acrobat file)

  13. Vulic, M., R. E. Lenski, and M. Radman. 1999. Mutation, recombination and incipient speciation of bacteria in the laboratory. Proceedings of the National Academy of Sciences, USA 96:7348-7351. (Abstract) (Acrobat file)

  14. De Visser, J. A. G. M., C. W. Zeyl, P. J. Gerrish, J. L. Blanchard, and R. E. Lenski. 1999. Diminishing returns from mutation supply rate in asexual populations. Science 283:404-406. (Abstract) (Acrobat file)

  15. Moxon, E. R., P. B. Rainey, and R. E. Lenski. 1998. Mutability and variability in disease (Letter). Perspectives in Biology and Medicine 42:154-155.

  16. Sniegowski, P. D., P. J. Gerrish, and R. E. Lenski. 1997. Evolution of high mutation rates in experimental populations of Escherichia coli. Nature 387:703-705. (Abstract) (Acrobat file)

  17. Sniegowski, P. D., and R. E. Lenski. 1995. Mutation and adaptation: the directed mutation controversy in evolutionary perspective. Annual Review of Ecology and Systematics 26:553-578. (Abstract) (Acrobat file)

  18. Lenski, R. E., and P. D. Sniegowski. 1995. "Adaptive mutation": the debate goes on (Letter). Science 269:285-286. (Abstract)

  19. Lenski, R. E., and P. D. Sniegowski. 1995. Directed mutations slip-sliding away? Current Biology 5:97-99. (Abstract)

  20. Moxon, E. R., P. B. Rainey, M. A. Nowak, and R. E. Lenski. 1994. Adaptive evolution of highly mutable loci in pathogenic bacteria. Current Biology 4:24-33. (Article)

  21. Lenski, R. E., and J. E. Mittler. 1993. Whither directed mutation? (Letter). Science 262:318-319.

  22. Lenski, R. E., and J. E. Mittler. 1993. Unusual mutational mechanisms and evolution (Technical Comment). Science 260:1959-1960.

  23. Lenski, R. E., and J. E. Mittler. 1993. Directed mutation (Letter). Science 260:1222-1224.

  24. Lenski, R. E., and J. E. Mittler. 1993. The directed mutation controversy and neo-Darwinism. Science 259:188-194. (Abstract) (Acrobat file)

  25. Mittler, J. E., and R. E. Lenski. 1992. Experimental evidence for an alternative to directed mutation in the bgl operon. Nature 356:446-448. (Abstract)

  26. Mittler, J. E., and R. E. Lenski. 1990. Causes of mutation and Mu excision (Scientific Correspondence). Nature 345:213.

  27. Mittler, J. E., and R. E. Lenski. 1990. New data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis. Nature 344:173-175. (Abstract) (Acrobat file)

  28. Lenski, R. E., M. Slatkin, and F. J. Ayala. 1989. Mutation and selection in bacterial populations: alternatives to the hypothesis of directed mutation. Proceedings of the National Academy of Sciences, USA 86:2775-2778. (Abstract) (Acrobat file)

  29. Lenski, R. E. 1989. Are some mutations directed? Trends in Ecology and Evolution 4:148-150. (Acrobat file)

  30. Lenski, R. E., M. Slatkin, and F. J. Ayala. 1989. Another alternative to directed mutation (Scientific Correspondence). Nature 337:123-124. (Abstract)

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