Interactions among mutations

  1. Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proceedings of the National Academy of Sciences, USA 105:7899-7906. (Abstract) (Acrobat file)

  2. Cooper, T. F., S. K. Remold, R. E. Lenski, and D. Schneider. 2008. Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli. PLoS Genetics 4:e35 [10 pp]. (Article)

  3. Beerenwinkel, N., L. Pachter, B. Sturmfels, S. F. Elena, and R. E. Lenski. 2007. Analysis of epistatic interactions and fitness landscapes using a new geometric approach. BMC Evolutionary Biology 7:60 [12 pp]. (Article)

  4. Elena, S. F., C. O. Wilke, C. Ofria, and R. E. Lenski. 2007. Effects of population size and mutation rate on the evolution of mutational robustness. Evolution 61:666-674. (Abstract)

  5. Misevic, D., C. Ofria, R. E. Lenski. 2006. Sexual reproduction reshapes the genetic architecture of digital organisms. Proceedings of the Royal Society, London B 273:457-464. (Link to PDF)

  6. Cooper, T. F., R. E. Lenski, and S. F. Elena. 2005. Parasites and mutational load: an experimental test of a pluralistic theory for the evolution of sex. Proceedings of the Royal Society, London B 272:311-317. (Article)

  7. Misevic, D., R. E. Lenski, and C. Ofria. 2004. Sexual reproduction and Muller's ratchet in digital organisms. Pp. 340-345 in J. Pollack, M. Bedau, P. Husbands, T. Ikegami, and R. A. Watson, eds. Artificial Life IX: Proceedings of the Ninth International Conference on the Simulation and Synthesis of Living Systems. MIT Press, Cambridge, Massachusetts. (Acrobat file)

  8. Remold, S. K., and R. E. Lenski. 2004. Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli. Nature Genetics 36:423-426. (Nature Genetics) (Acrobat file)

  9. Wilke, C. O., R. E. Lenski, and C. Adami. 2003. Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding. BMC Evolutionary Biology 3:3. (Link)

  10. Cooper, T. F., D. E. Rozen, and R. E. Lenski. 2003. Parallel changes in gene expression after 20,000 generations of evolution in E. coli. Proceedings of the National Academy of Sciences, USA 100:1072-1077. (Abstract) (Acrobat file)

  11. Lenski, R. E. 2001. Come fly, and leave the baggage behind (Perspective). Science 294:533-534. (Reprint) (Acrobat file)

  12. Elena, S. F., and R. E. Lenski. 2001. Epistasis between new mutations and genetic background and a test of genetic canalization. Evolution 55:1746-1752. (Abstract) (Acrobat file)

  13. Remold, S. K., and R. E. Lenski. 2001. Contribution of individual random mutations to genotype-by-environment interactions in Escherichia coli. Proceedings of the National Academy of Sciences, USA 98:11388-11393. (Abstract) (Acrobat file)

  14. Wilke, C. O, J. Wang, C. Ofria, R. E. Lenski, and C. Adami. 2001. Evolution of digital organisms at high mutation rate leads to survival of the flattest. Nature 412:331-333. (Abstract) (Acrobat file)

  15. Moore, F. B-G., D. E. Rozen, and R. E. Lenski. 2000. Pervasive compensatory adaptation in Escherichia coli. Proceedings of the Royal Society, London B, 267:515-522. (Abstract) (Acrobat file)

  16. Lenski, R. E., C. Ofria, T. C. Collier, and C. Adami. 1999. Genome complexity, robustness, and genetic interactions in digital organisms. Nature 400:661-664. (Link) (Acrobat file)

  17. Bohannan, B. J. M., M. Travisano, and R. E. Lenski. 1999. Epistatic interactions can lower the cost of resistance to multiple consumers. Evolution 53:292-295. (Abstract) (Acrobat file)

  18. Elena, S. F., L. Ekunwe, N. Hajela, S. A. Oden, and R. E. Lenski. 1998. Distribution of fitness effects caused by random insertion mutations in Escherichia coli. Genetica 102/103:349-358. (Abstract) (Acrobat file)

  19. Elena, S. F., and R. E. Lenski. 1997. Test of synergistic interactions among deleterious mutations in bacteria. Nature 390:395-398. (Abstract) (Acrobat file)

  20. Lenski, R. E., V. Souza, L. P. Duong, Q. G. Phan, T. N. M. Nguyen, and K. P. Bertrand. 1994. Epistatic effects of promoter and repressor functions of the Tn10 tetracycline-resistance operon on the fitness of Escherichia coli. Molecular Ecology 3:127-135. (Acrobat file)

  21. Lenski, R. E. 1988. Experimental studies of pleiotropy and epistasis in Escherichia coli. II. Compensation for maladaptive pleiotropic effects associated with resistance to virus T4. Evolution 42:433-440. (Acrobat file)

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