Long-term evolution experiment with E.coli

  1. Barrick, J. E., and R. E. Lenski. Genome-wide mutational diversity in an evolving population of Escherichia coli. Cold Spring Harbor Symposia on Quantitative Biology 74: in press. [doi: 10.1101/sqb.2009.74.018] (Abstract)

  2. Stanek, M. T, T. F. Cooper, and R. E. Lenski. 2009. Identification and dynamics of a beneficial mutation in a long-term evolution experiment with Escherichia coli. BMC Evolutionary Biology 9:302 [13 pp]. (Abstract)

  3. Barrick, J. E., D. S. Yu, S. H. Yoon, H. Jeong, T. K. Oh, D. Schneider, R. E. Lenski, and J. F. Kim. 2009. Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature 461:1243-1247. (Abstract)

  4. Studier, F. W., P. Daegelen, R. E. Lenski, S. Maslov, and J. F. Kim. 2009. Understanding the differences between genome sequences of Escherichia coli B strains REL606 and BL21(DE3) and comparison of the E. coli B and K-12 genomes. Journal of Molecular Biology 394:653-680. (Abstract)

  5. Jeong, H., V. Barbe, C. H. Lee, D. Vallenet, D. S. Yu, S.-H. Choi, A. Couloux, S.-W. Lee, S. H. Yoon, L. Cattolico, C.-G. Hur, H.-S. Park, B. Ségurens, S. C. Kim, T. K. Oh, R. E. Lenski, F. W. Studier, P. Daegelen, and J. F. Kim. 2009. Genome sequences of Escherichia coli B strains REL606 and BL21(DE3). Journal of Molecular Biology 394:644-652. (Abstract)

  6. Daegelen, P., F. W. Studier, R. E. Lenski, S. Cure, and J. F. Kim. 2009. Tracing ancestors and relatives of Escherichia coli B, and the derivation of B strains REL606 and BL21(DE3). Journal of Molecular Biology 394:634-643. (Abstract)

  7. Philippe, N., L. Pelosi, R. E. Lenski, and D. Schneider. 2009. Evolution of penicillin-binding protein 2 concentration and cell shape during a long-term experiment with Escherichia coli. Journal of Bacteriology 191:909-921. (Abstract)

  8. Rozen, D. E., N. Philippe, J. A. de Visser, R. E. Lenski, and D. Schneider. 2009. Death and cannibalism in a seasonal environment facilitate bacterial coexistence. Ecology Letters 12:34-44. (Abstract)

  9. Blount, Z. D., C. Z. Borland, and R. E. Lenski. 2008. Historical contingency and the evolution of a key innovation in an experimental population of Escherichia coli. Proceedings of the National Academy of Sciences, USA 105:7899-7906. (Abstract) (Acrobat file)

  10. Cooper, T. F., S. K. Remold, R. E. Lenski, and D. Schneider. 2008. Expression profiles reveal parallel evolution of epistatic interactions involving the CRP regulon in Escherichia coli. PLoS Genetics 4:e35 [10 pp]. (Article)

  11. Ostrowski, E. A., R. J. Woods, and R. E. Lenski. 2008. The genetic basis of parallel and divergent phenotypic responses in evolving populations of Escherichia coli. Proceedings of the Royal Society, London B 275:277-284. (Abstract)

  12. Philippe, N., E. Crozat, R. E. Lenski, and D. Schneider. 2007. Evolution of global regulatory networks during a long-term experiment with Escherichia coli. BioEssays 29:846-860. (Abstract)

  13. Sleight, S. C, N. S. Wigginton, and R. E. Lenski. 2006. Increased susceptibility to repeated freeze-thaw cycles in Escherichia coli following long-term evolution in a benign environment. BMC Evolutionary Biology 6:104 [8 pp]. (Abstract)

  14. Pelosi, L., L. Kühn, D. Guetta, J. Garin, J. Geiselmann, R. E. Lenski, and D. Schneider. 2006. Parallel changes in global protein profiles during long-term experimental evolution in Escherichia coli. Genetics 173:1851-1869. (Abstract)

  15. Novak, M., T. Pfeiffer, R. E. Lenski, U. Sauer, and S. Bonhoeffer. 2006. Experimental tests for an evolutionary trade-off between growth rate and yield in E. coli. American Naturalist 168:242-251. (Abstract)

  16. Woods, R., D. Schneider, C. L. Winkworth, M. A. Riley, and R. E. Lenski. 2006. Tests of parallel molecular evolution in a long-term experiment with Escherichia coli. Proceedings of the National Academy of Sciences, USA 103:9107-9112. (PNAS)

  17. Ostrowski, E. A., D. E. Rozen, and R. E. Lenski. 2005. Pleiotropic effects of beneficial mutations in Escherichia coli. Evolution 59:2343-2352. (Abstract)

  18. Rozen, D. E., D. Schneider, and R. E. Lenski. 2005. Long-term experimental evolution in Escherichia coli. XIII. Phylogenetic history of a balanced polymorphism. Journal of Molecular Evolution 61:171-180. (Journal link)

  19. Crozat, E., N. Philippe, R. E. Lenski, J. Geiselmann, and D. Schneider. 2005. Long-term experimental evolution in Escherichia coli. XII. DNA topology as a key target of selection. Genetics 169:523-532. (Abstract)

  20. Lenski, R. E. 2004. Phenotypic and genomic evolution during a 20,000-generation experiment with the bacterium Escherichia coli. Plant Breeding Reviews 24:225-265. (Acrobat file)

  21. Lenski, R. E., C. L. Winkworth, and M. A. Riley. 2003. Rates of DNA sequence evolution in experimental populations of Escherichia coli during 20,000 generations. Journal of Molecular Evolution 56:498-508. (Abstract) (Acrobat file)

  22. Cooper, T. F., D. E. Rozen, and R. E. Lenski. 2003. Parallel changes in gene expression after 20,000 generations of evolution in E. coli. Proceedings of the National Academy of Sciences, USA 100:1072-1077. (Abstract) (Acrobat file)

  23. De Visser, J. A. G. M., and R. E. Lenski. 2002. Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation. BMC Evolutionary Biology 2:19. (Link)

  24. Lenski, R. E. 2002. Experimental evolution: a long-term study with E. coli. Pp. 342-344 in M. Pagel, S. Frank, C. Godfray, B. K. Hall, K. Hawkes, D. M. Hillis, A. Kodric-Brown, R. E. Lenski, and A. Pomiankowski, eds. Encyclopedia of Evolution. Oxford University Press, New York. (Order)

  25. Lenski, R. E. 2001. Testing Antonovics' five tenets of ecological genetics: experiments with bacteria at the interface of ecology and genetics. Pp. 25-45 in M. C. Press, N. Huntly, and S. Levin, eds. Ecology: Achievement and Challenge. Blackwell Science, Oxford. (Acrobat file)

  26. Cooper, V. S., A. F. Bennett, and R. E. Lenski. 2001. Evolution of thermal dependence of growth rate of Escherichia coli populations during 20,000 generations in a constant environment. Evolution 55:889-896. (Abstract) (Acrobat file)

  27. Cooper, V. S., D. Schneider, M. Blot, and R. E. Lenski. 2001. Mechanisms causing rapid and parallel losses of ribose catabolism in evolving populations of E. coli B. Journal of Bacteriology 183:2834-2841. (Abstract) (Acrobat file)

  28. Cooper, V. S., and R. E. Lenski. 2000. The population genetics of ecological specialization in evolving E. coli populations. Nature 407:736-739. (Abstract) (Acrobat file)

  29. Schneider, D., E. Duperchy, E. Coursange, R. E. Lenski, and M. Blot. 2000. Long-term experimental evolution in Escherichia coli. IX. Characterization of IS-mediated mutations and rearrangements. Genetics 156:477-488. (Abstract) (Acrobat file)

  30. Lenski, R. E., and J. A. Mongold. 2000. Cell size, shape, and fitness in evolving populations of bacteria. Pp. 221-235 in J. H. Brown and G. B. West, eds. Scaling in Biology. Oxford University Press.

  31. Rozen, D. E., and R. E. Lenski. 2000. Long-term experimental evolution in Escherichia coli. VIII. Dynamics of a balanced polymorphism. American Naturalist 155:24-35. (Abstract) (Acrobat file)

  32. Vasi, F. K., and R. E. Lenski. 1999. Ecological strategies and fitness tradeoffs in Escherichia coli mutants adapted to prolonged starvation. Journal of Genetics 78:43-49. (Abstract) (Acrobat file)

  33. Vulic, M., R. E. Lenski, and M. Radman. 1999. Mutation, recombination and incipient speciation of bacteria in the laboratory. Proceedings of the National Academy of Sciences, USA 96:7348-7351. (Abstract) (Acrobat file)

  34. Papadopoulos, D., D. Schneider, J. Meier-Eiss, W. Arber, R. E. Lenski, and M. Blot. 1999. Genomic evolution during a 10,000-generation experiment with bacteria. Proceedings of the National Academy of Sciences, USA 96:3807-3812. (Abstract) (Acrobat file)

  35. Gerrish, P. J., and R. E. Lenski. 1998. The fate of competing beneficial mutations in an asexual population. Genetica 102/103:127-144. (Abstract) (Acrobat file)

  36. Lenski, R. E., J. A. Mongold, P. D. Sniegowski, M. Travisano, F. Vasi, P. J. Gerrish, and T. Schmidt. 1998. Evolution of competitive fitness in experimental populations of E. coli: What makes one genotype a better competitor than another? Antonie van Leeuwenhoek 73:35-47. (Abstract) (Acrobat file)

  37. Elena, S. F., and R. E. Lenski. 1997. Long-term experimental evolution in Escherichia coli. VII. Mechanisms maintaining genetic variability within populations. Evolution 51:1058-1067. (Abstract) (Acrobat file)

  38. Souza, V., P. E. Turner, and R. E. Lenski. 1997. Long-term experimental evolution in Escherichia coli. V. Effects of recombination with immigrant genotypes on the rate of bacterial evolution. Journal of Evolutionary Biology 10:743-769. (Abstract) (Acrobat file)

  39. Sniegowski, P. D., P. J. Gerrish, and R. E. Lenski. 1997. Evolution of high mutation rates in experimental populations of Escherichia coli. Nature 387:703-705. (Abstract) (Acrobat file)

  40. Elena, S. F., V. S. Cooper, and R. E. Lenski. 1996. Mechanisms of punctuated evolution. (Technical Comment). Science 274:1749-1750.

  41. Turner, P. E., V. Souza, and R. E. Lenski. 1996. Tests of ecological mechanisms promoting the stable coexistence of two bacterial genotypes. Ecology 77:2119-2129. (Abstract) (Acrobat file)

  42. Mongold, J. A., and R. E. Lenski. 1996. Experimental rejection of a nonadaptive explanation for increased cell size in Escherichia coli. Journal of Bacteriology 178: 5333-5334. (Abstract) (Acrobat file)

  43. Elena, S. F., V. S. Cooper, and R. E. Lenski. 1996. Punctuated evolution caused by selection of rare beneficial mutations. Science 272:1802-1804. (Abstract) (Acrobat file)

  44. Travisano, M., and R. E. Lenski. 1996. Long-term experimental evolution in Escherichia coli. IV. Targets of selection and the specificity of adaptation. Genetics 143:15-26. (Abstract)

  45. Travisano, M., F. Vasi, and R. E. Lenski. 1995. Long-term experimental evolution in Escherichia coli. III. Variation among replicate populations in correlated responses to novel environments. Evolution 49:189-200. (Abstract) (Acrobat file)

  46. Johnson, P. A., R. E. Lenski, and F. C. Hoppensteadt. 1995. Theoretical analysis of divergence in mean fitness between initially identical populations. Proceedings of the Royal Society, London B 259:125-130. (Abstract) (Acrobat file)

  47. Travisano, M., J. A. Mongold, A. F. Bennett, and R. E. Lenski. 1995. Experimental tests of the roles of adaptation, chance, and history in evolution. Science 267:87-90. (Abstract) (Acrobat file)

  48. Vasi, F., M. Travisano, and R. E. Lenski. 1994. Long-term experimental evolution in Escherichia coli. II. Changes in life-history traits during adaptation to a seasonal environment. American Naturalist 144:432-456. (Abstract) (Acrobat file)

  49. Lenski, R. E., and M. Travisano. 1994. Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations. Proceedings of the National Academy of Sciences, USA 91:6808-6814. [Reprinted: Pp. 253-273 in F. J. Ayala and W. M. Fitch, editors. 1995. Tempo and Mode in Evolution: Genetics and Paleontology 50 Years after Simpson. National Academy Press, Washington, DC.] (Abstract) (Acrobat file)

  50. Lenski, R. E., M. R. Rose, S. C. Simpson, and S. C. Tadler. 1991. Long-term experimental evolution in Escherichia coli. I. Adaptation and divergence during 2,000 generations. American Naturalist 138:1315-1341. (Abstract) (Acrobat file)

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